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Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model

The therapeutic management of chronic pain associated with many cancers is problematic due to development of tolerance and other adverse effects during the disease progression. Recently we reported on a bivalent ligand (MMG22) containing both mu agonist and mGluR(5) antagonist pharmacophores that pr...

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Détails bibliographiques
Publié dans:Eur J Pharmacol
Auteurs principaux: Smeester, Branden A., Lunzer, Mary M., Akgün, Eyup, Beitz, Alvin J., Portoghese, Philip S.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259840/
https://ncbi.nlm.nih.gov/pubmed/25239072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2014.09.008
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