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Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia

Sickle cell anemia is a common genetic disorder in African Americans. Opioid analgesics are traditionally the treatment for the severe pain associated with this disease. Here we reveal that the opioid antagonist naloxone possesses potent analgesic activity in two transgenic mouse models of sickle ce...

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Bibliografske podrobnosti
Main Authors: Lunzer, Mary M., Yekkirala, Ajay, Hebbel, Robert P., Portoghese, Philip S.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851616/
https://ncbi.nlm.nih.gov/pubmed/17389363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700295104
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