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An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands

Bivalent ligands that contain two pharmacophores linked by a spacer are promising tools to investigate the pharmacology of opioid receptor heteromers. Evidence for occupation of neighboring protomers by two phamacophores of a single bivalent ligand (bridging) has relied mainly on pharmacological dat...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Yekkirala, Ajay S., Kalyuzhny, Alexander E, Portoghese, Philip S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5060010/
https://ncbi.nlm.nih.gov/pubmed/23675763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400113d
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