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A bivalent ligand (KMN-21) antagonist for μ/κ heterodimeric opioid receptors
In an effort to develop antagonists for κ-μ opioid receptor heterodimers, a series of bivalent ligands 3 - 6 containing κ- and μ-antagonist pharmacophores were designed and synthesized. Evaluation of the series in HEK-293 cells revealed 4 (KMN-21) to selectively antagonize the activation of κ-μ hete...
Gorde:
| Argitaratua izan da: | Bioorg Med Chem Lett |
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| Egile Nagusiak: | , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2009
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5060004/ https://ncbi.nlm.nih.gov/pubmed/19892550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.10.045 |
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