Standard Opioid Agonists Activate Heteromeric Opioid Receptors: Evidence for Morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]Enkephalin as Selective μ−δ Agonists

Por Yekkirala, Ajay S., Kalyuzhny, Alexander E., Portoghese, Philip S.
Publicado em 2009

An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands

Por Yekkirala, Ajay S., Kalyuzhny, Alexander E, Portoghese, Philip S.
Publicado no ACS Chem Biol (2013)

A bivalent ligand (KMN-21) antagonist for μ/κ heterodimeric opioid receptors

Por Zhang, Shijun, Yekkirala, Ajay, Tang, Ye, Portoghese, Philip S.
Publicado no Bioorg Med Chem Lett (2009)

Basic/translational Development of Forthcoming Opioid and Non-Opioid Targeted Pain Therapeutics

Por Knezevic, Nebojsa Nick, Yekkirala, Ajay, Yaksh, Tony L.
Publicado no Anesth Analg (2017)

Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia

Por Lunzer, Mary M., Yekkirala, Ajay, Hebbel, Robert P., Portoghese, Philip S.
Publicado em 2007

Breaking barriers to novel analgesic drug development

Por Yekkirala, Ajay S, Roberson, David P, Bean, Bruce P., Woolf, Clifford J.
Publicado no Nat Rev Drug Discov (2017)

Breaking barriers to novel analgesic drug development

Por Yekkirala, Ajay S., Roberson, David P., Bean, Bruce P., Woolf, Clifford J.
Publicado no Nat Rev Drug Discov (2017)

Clinically Employed Opioid Analgesics Produce Antinociception via μ-δ Opioid Receptor Heteromers in Rhesus Monkeys

Por Yekkirala, Ajay S., Banks, Matthew L., Lunzer, Mary M., Negus, Stevens S., Rice, Kenner C., Portoghese, Philip S.
Publicado em 2012

Bivalent ligands that target mu opioid (MOP) and cannabinoid1 (CB(1)) receptors are potent analgesics devoid of tolerance

Por Naour, Morgan Le, Akgün, Eyup, Yekkirala, Ajay, Lunzer, Mary M., Powers, Mike D., Kalyuzhny, Alexander E., Portoghese, Philip S.
Publicado em 2013

The δ Opioid Receptor Agonist SNC80 Selectively Activates Heteromeric μ–δ Opioid Receptors

Por Metcalf, Matthew D., Yekkirala, Ajay S., Powers, Michael D., Kitto, Kelley F., Fairbanks, Carolyn A., Wilcox, George L., Portoghese, Philip S.
Publicado em 2012

N-naphthoyl-β-naltrexamine (NNTA), a highly selective and potent activator of μ/κ-opioid heteromers

Por Yekkirala, Ajay S., Lunzer, Mary M., McCurdy, Christopher R., Powers, Michael D., Kalyuzhny, Alexander E., Roerig, Sandra C., Portoghese, Philip S.
Publicado em 2011

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program

Por Chandran, Vijayendran, Coppola, Giovanni, Nawabi, Homaira, Omura, Takao, Versano, Revital, Huebner, Eric A., Zhang, Alice, Costigan, Michael, Yekkirala, Ajay, Barrett, Lee, Blesch, Armin, Michaelevski, Izhak, Davis-Turak, Jeremy, Gao, Fuying, Langfelder, Peter, Horvath, Steve, He, Zhigang, Benowitz, Larry, Fainzilber, Mike, Tuszynski, Mark, Woolf, Clifford J., Geschwind, Daniel H.
Publicado no Neuron (2016)

Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain

Por Sisignano, Marco, Angioni, Carlo, Park, Chul-Kyu, Meyer Dos Santos, Sascha, Jordan, Holger, Kuzikov, Maria, Liu, Di, Zinn, Sebastian, Hohman, Stephan W., Schreiber, Yannick, Zimmer, Béla, Schmidt, Mike, Lu, Ruirui, Suo, Jing, Zhang, Dong-Dong, Schäfer, Stephan M. G., Hofmann, Martine, Yekkirala, Ajay S., de Bruin, Natasja, Parnham, Michael J., Woolf, Clifford J., Ji, Ru-Rong, Scholich, Klaus, Geisslinger, Gerd
Publicado no Proc Natl Acad Sci U S A (2016)