Sorting receptor SORLA: cellular mechanisms and implications for disease

Por Schmidt, Vanessa, Subkhangulova, Aygul, Willnow, Thomas E.
Publicado no Cell Mol Life Sci (2016)

Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo.

Por Willnow, T E, Armstrong, S A, Hammer, R E, Herz, J
Publicado em 1995

Risk factor SORL1: from genetic association to functional validation in Alzheimer’s disease

Por Andersen, Olav M., Rudolph, Ina-Maria, Willnow, Thomas E.
Publicado no Acta Neuropathol (2016)

Multi-compartmental modeling of SORLA’s influence on amyloidogenic processing in Alzheimer’s disease

Por Lao, Angelyn, Schmidt, Vanessa, Schmitz, Yvonne, Willnow, Thomas E, Wolkenhauer, Olaf
Publicado em 2012

The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.

Por Willnow, T E, Moehring, J M, Inocencio, N M, Moehring, T J, Herz, J
Publicado em 1996

SORLA-Mediated Trafficking of TrkB Enhances the Response of Neurons to BDNF

Por Rohe, Michael, Hartl, Daniela, Fjorback, Anja Nawarecki, Klose, Joachim, Willnow, Thomas E.
Publicado em 2013

beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin.

Por Moestrup, S K, Schousboe, I, Jacobsen, C, Leheste, J R, Christensen, E I, Willnow, T E
Publicado em 1998

Megalin Participates in the Early Injury of Proximal Tubule Cells in Glomerular Disease with Non-selective Proteinuria

Por Motoyoshi, Yaeko, Matsusaka, Taiji, Saito, Akihiko, Pastan, Ira, Willnow, Thomas E., Mizutani, Shuki, Ichikawa, Iekuni
Publicado em 2008

Soluble Alpha-APP (sAPPalpha) Regulates CDK5 Expression and Activity in Neurons

Por Hartl, Daniela, Klatt, Stephan, Roch, Manfred, Konthur, Zoltan, Klose, Joachim, Willnow, Thomas E., Rohe, Michael
Publicado em 2013

Defective forebrain development in mice lacking gp330/megalin.

Por Willnow, T E, Hilpert, J, Armstrong, S A, Rohlmann, A, Hammer, R E, Burns, D K, Herz, J
Publicado em 1996

RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors.

Por Willnow, T E, Rohlmann, A, Horton, J, Otani, H, Braun, J R, Hammer, R E, Herz, J
Publicado em 1996

Efficient eukaryotic expression system for authentic human sex hormone-binding globulin.

Por Hilpert, J, Vorum, H, Burmeister, R, Spoelgen, R, Grishkovskaya, I, Misselwitz, R, Nykjaer, A, Willnow, T E
Publicado em 2001

Cadm2 regulates body weight and energy homeostasis in mice

Por Yan, Xin, Wang, Zhen, Schmidt, Vanessa, Gauert, Anton, Willnow, Thomas E., Heinig, Matthias, Poy, Matthew N.
Publicado no Mol Metab (2017)

Identification of a Linear Epitope in Sortilin That Partakes in Pro-neurotrophin Binding

Por Serup Andersen, Olga, Boisguerin, Prisca, Glerup, Simon, Skeldal, Sune, Volkmer, Rudolf, Willnow, Thomas E., Nykjær, Anders, Andersen, Olav M.
Publicado em 2010

Sortilin-Related Receptor SORCS3 Is a Postsynaptic Modulator of Synaptic Depression and Fear Extinction

Por Breiderhoff, Tilman, Christiansen, Gitte B., Pallesen, Lone T., Vaegter, Christian, Nykjaer, Anders, Holm, Mai Marie, Glerup, Simon, Willnow, Thomas E.
Publicado em 2013

Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis

Por Breiderhoff, Tilman, Himmerkus, Nina, Stuiver, Marchel, Mutig, Kerim, Will, Constanze, Meij, Iwan C., Bachmann, Sebastian, Bleich, Markus, Willnow, Thomas E., Müller, Dominik
Publicado em 2012

SORLA-Dependent and -Independent Functions for PACS1 in Control of Amyloidogenic Processes

Por Burgert, Tilman, Schmidt, Vanessa, Caglayan, Safak, Lin, Fuyu, Füchtbauer, Annette, Füchtbauer, Ernst-Martin, Nykjaer, Anders, Carlo, Anne-Sophie, Willnow, Thomas E.
Publicado em 2013

Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cells

Por Nielsen, Rikke, Courtoy, Pierre J., Jacobsen, Christian, Dom, Geneviève, Lima, Wânia Rezende, Jadot, Michel, Willnow, Thomas E., Devuyst, Olivier, Christensen, Erik I.
Publicado em 2007

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity

Por Schmidt, Vanessa, Schulz, Nadja, Yan, Xin, Schürmann, Annette, Kempa, Stefan, Kern, Matthias, Blüher, Matthias, Poy, Matthew N., Olivecrona, Gunilla, Willnow, Thomas E.
Publicado no J Clin Invest (2016)

Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia

Por Kozyraki, Renata, Fyfe, John, Verroust, Pierre J., Jacobsen, Christian, Dautry-Varsat, Alice, Gburek, Jakub, Willnow, Thomas E., Christensen, Erik Ilsø, Moestrup, Søren K.
Publicado em 2001