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Soluble Alpha-APP (sAPPalpha) Regulates CDK5 Expression and Activity in Neurons

A growing body of evidence suggests a role for soluble alpha-amyloid precursor protein (sAPPalpha) in pathomechanisms of Alzheimer disease (AD). This cleavage product of APP was identified to have neurotrophic properties. However, it remained enigmatic what proteins, targeted by sAPPalpha, might be...

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Autori principali: Hartl, Daniela, Klatt, Stephan, Roch, Manfred, Konthur, Zoltan, Klose, Joachim, Willnow, Thomas E., Rohe, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679172/
https://ncbi.nlm.nih.gov/pubmed/23776568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065920
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