Soluble Alpha-APP (sAPPalpha) Regulates CDK5 Expression and Activity in Neurons

A growing body of evidence suggests a role for soluble alpha-amyloid precursor protein (sAPPalpha) in pathomechanisms of Alzheimer disease (AD). This cleavage product of APP was identified to have neurotrophic properties. However, it remained enigmatic what proteins, targeted by sAPPalpha, might be...

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Bibliografiske detaljer
Main Authors: Hartl, Daniela, Klatt, Stephan, Roch, Manfred, Konthur, Zoltan, Klose, Joachim, Willnow, Thomas E., Rohe, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679172/
https://ncbi.nlm.nih.gov/pubmed/23776568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065920
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