Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis

In the kidney, tight junction proteins contribute to segment specific selectivity and permeability of paracellular ion transport. In the thick ascending limb (TAL) of Henle's loop, chloride is reabsorbed transcellularly, whereas sodium reabsorption takes transcellular and paracellular routes. T...

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Detalhes bibliográficos
Main Authors: Breiderhoff, Tilman, Himmerkus, Nina, Stuiver, Marchel, Mutig, Kerim, Will, Constanze, Meij, Iwan C., Bachmann, Sebastian, Bleich, Markus, Willnow, Thomas E., Müller, Dominik
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435183/
https://ncbi.nlm.nih.gov/pubmed/22891322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203834109
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