Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis

In the kidney, tight junction proteins contribute to segment specific selectivity and permeability of paracellular ion transport. In the thick ascending limb (TAL) of Henle's loop, chloride is reabsorbed transcellularly, whereas sodium reabsorption takes transcellular and paracellular routes. T...

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Main Authors: Breiderhoff, Tilman, Himmerkus, Nina, Stuiver, Marchel, Mutig, Kerim, Will, Constanze, Meij, Iwan C., Bachmann, Sebastian, Bleich, Markus, Willnow, Thomas E., Müller, Dominik
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435183/
https://ncbi.nlm.nih.gov/pubmed/22891322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203834109
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