Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na(+) and Mg(2+) transport

The thick ascending limb (TAL) of Henle’s loop drives paracellular Na(+), Ca(2+), and Mg(2+) reabsorption via the tight junction (TJ). The TJ is composed of claudins that consist of four transmembrane segments, two extracellular segments (ECS1 and -2), and one intracellular loop. Claudins interact w...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Milatz, Susanne, Himmerkus, Nina, Wulfmeyer, Vera Christine, Drewell, Hoora, Mutig, Kerim, Hou, Jianghui, Breiderhoff, Tilman, Müller, Dominik, Fromm, Michael, Bleich, Markus, Günzel, Dorothee
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240732/
https://ncbi.nlm.nih.gov/pubmed/28028216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611684114
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