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Disease-associated mutations affect intracellular traffic and paracellular Mg(2+) transport function of Claudin-16
Claudin-16 (Cldn16) is selectively expressed at tight junctions (TJs) of renal epithelial cells of the thick ascending limb of Henle’s loop, where it plays a central role in the reabsorption of divalent cations. Over 20 different mutations in the CLDN16 gene have been identified in patients with fam...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1395478/ https://ncbi.nlm.nih.gov/pubmed/16528408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26323 |
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