Identification of a Linear Epitope in Sortilin That Partakes in Pro-neurotrophin Binding

Sortilin acts as a cell surface receptor for pro-neurotrophins (pro-NT) that upon complex formation with the p75 neurotrophin receptor (p75(NTR)) is able to signal neuronal cell death. Here we screened a sortilin peptide library comprising 16-mer overlapping sequences for binding of the pro-domains...

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Detalhes bibliográficos
Main Authors: Serup Andersen, Olga, Boisguerin, Prisca, Glerup, Simon, Skeldal, Sune, Volkmer, Rudolf, Willnow, Thomas E., Nykjær, Anders, Andersen, Olav M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852960/
https://ncbi.nlm.nih.gov/pubmed/20159974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.062364
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