Sortilin associates with Trk receptors to enhance anterograde transport and signaling by neurotrophins

Binding of target-derived neurotrophins to Trk receptors at nerve terminals are required to stimulate neuronal survival, differentiation, innervation and synaptic plasticity. The distance between the soma and nerve terminal is tremendous, making efficient anterograde Trk transport critical for their...

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Autori principali: Vaegter, Christian B., Jansen, Pernille, Fjorback, Anja W., Glerup, Simon, Skeldal, Sune, Richner, Mette, Erdmann, Bettina, Nyengaard, Jens R., Tessarollo, Lino, Lewin, Gary R., Willnow, Thomas E., Chao, Moses V., Nykjaer, Anders
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808973/
https://ncbi.nlm.nih.gov/pubmed/21102451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2689
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