Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis

Neurotrophins comprise a group of neuronal growth factors that are essential for the development and maintenance of the nervous system. However, the immature pro-neurotrophins promote apoptosis by engaging in a complex with sortilin and the p75 neurotrophin receptor (p75(NTR)). To identify the inter...

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Bibliografiska uppgifter
Huvudupphovsmän: Skeldal, Sune, Sykes, Alex M., Glerup, Simon, Matusica, Dusan, Palstra, Nickless, Autio, Henri, Boskovic, Zoran, Madsen, Peder, Castrén, Eero, Nykjaer, Anders, Coulson, Elizabeth J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2012
Ämnen:
Neurobiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527964/
https://ncbi.nlm.nih.gov/pubmed/23105113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.374710
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