Spontaneous and Engineered Large Animal Models of Neurofibromatosis Type 1

per Osum, Sara H., Watson, Adrienne L., Largaespada, David A.
Publicat a Int J Mol Sci (2021)

Multiphoton fluorescence lifetime imaging of chemotherapy distribution in solid tumors

per Carlson, Marjorie, Watson, Adrienne L., Anderson, Leah, Largaespada, David A., Provenzano, Paolo P.
Publicat a J Biomed Opt (2017)

Engineered Swine Models of Cancer

per Watson, Adrienne L., Carlson, Daniel F., Largaespada, David A., Hackett, Perry B., Fahrenkrug, Scott C.
Publicat a Front Genet (2016)

Identification of candidate neoantigens produced by fusion transcripts in human osteosarcomas

per Rathe, Susan K., Popescu, Flavia E., Johnson, James E., Watson, Adrienne L., Marko, Tracy A., Moriarity, Branden S., Ohlfest, John R., Largaespada, David A.
Publicat a Sci Rep (2019)

MMuFLR: missense mutation and frameshift location reporter

per Rathe, Susan K., Johnson, James E., Silverstein, Kevin A.T., Erdmann, Jesse J., Watson, Adrienne L., Popescu, Flavia E., Ohlfest, John R., Largaespada, David A.
Publicat 2013

PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve...

per Keng, Vincent W., Rahrmann, Eric P., Watson, Adrienne L., Tschida, Barbara R., Moertel, Christopher L., Jessen, Walter J., Rizvi, Tilat A., Collins, Margaret H., Ratner, Nancy, Largaespada, David A.
Publicat 2012

Mammalian germ cells are determined after PGC colonization of the nascent gonad

per Nicholls, Peter K., Schorle, Hubert, Naqvi, Sahin, Hu, Yueh-Chiang, Fan, Yuting, Carmell, Michelle A., Dobrinski, Ina, Watson, Adrienne L., Carlson, Daniel F., Fahrenkrug, Scott C., Page, David C.
Publicat a Proc Natl Acad Sci U S A (2019)

Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST

per Keng, Vincent W., Watson, Adrienne L., Rahrmann, Eric P., Li, Hua, Tschida, Barbara R., Moriarity, Branden S., Choi, Kwangmin, Rizvi, Tilat A., Collins, Margaret H., Wallace, Margaret R., Ratner, Nancy, Largaespada, David A.
Publicat 2012

Simple and Efficient Methods for Enrichment and Isolation of Endonuclease Modified Cells

per Moriarity, Branden S., Rahrmann, Eric P., Beckmann, Dominic A., Conboy, Caitlin B., Watson, Adrienne L., Carlson, Daniel F., Olson, Erik R., Hyland, Kendra A., Fahrenkrug, Scott C., McIvor, R. Scott, Largaespada, David A.
Publicat 2014

Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity

per Watson, Adrienne L., Anderson, Leah K., Greeley, Andrew D., Keng, Vincent W., Rahrmann, Eric P., Halfond, Amanda L., Powell, Natasha M., Collins, Margaret H., Rizvi, Tilat, Moertel, Christopher L., Ratner, Nancy, Largaespada, David A.
Publicat 2014

Trp53 Haploinsufficiency Modifies EGFR-Driven Peripheral Nerve Sheath Tumorigenesis

per Rahrmann, Eric P., Moriarity, Branden S., Otto, George M., Watson, Adrienne L., Choi, Kwangmin, Collins, Margaret H., Wallace, Margaret, Webber, Beau R., Forster, Colleen L., Rizzardi, Anthony E., Schmechel, Stephen C., Ratner, Nancy, Largaespada, David A.
Publicat 2014

Selumetinib normalizes Ras/MAPK signaling in clinically relevant neurofibromatosis type 1 minipig tissues in vivo

per Osum, Sara H, Coutts, Alexander W, Duerre, Dylan J, Tschida, Barbara R, Kirstein, Mark N, Fisher, James, Bell, W Robert, Delpuech, Oona, Smith, Paul D, Widemann, Brigitte C, Moertel, Christopher L, Largaespada, David A, Watson, Adrienne L
Publicat a Neurooncol Adv (2021)

Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and genetic pathways driving tumorigenesis

per Rahrmann, Eric P, Watson, Adrienne L, Keng, Vincent W, Choi, Kwangmin, Moriarity, Branden S, Beckmann, Dominic A, Wolf, Natalie, Sarver, Aaron, Collins, Margaret H, Moertel, Christopher L, Wallace, Margaret R, Gel, Bernat, Serra, Eduard, Ratner, Nancy, Largaespada, David A
Publicat 2013

Correction: Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity

per Watson, Adrienne L., Keller, Bryant J., Williams, Kyle A., Damle, Namrata N., Finnerty, Samuel J., Anderson, Leah K., Greeley, Andrew D., Keng, Vincent W., Rahrmann, Eric P., Halfond, Amanda L., Powell, Natasha M., Collins, Margaret H., Rizvi, Tilat, Moertel, Christopher L., Ratner, Nancy, Largaespada, David A.
Publicat a Oncotarget (2020)

Development of a porcine model of phenylketonuria with a humanized R408W mutation for gene editing

per Kaiser, Robert A., Carlson, Daniel F., Allen, Kari L., Webster, Dennis A., VanLith, Caitlin J., Nicolas, Clara T., Hillin, Lori G., Yu, Yue, Kaiser, Catherine W., Wahoff, William R., Hickey, Raymond D., Watson, Adrienne L., Winn, Shelley R., Thöny, Beat, Kern, Douglas R., Harding, Cary O., Lillegard, Joseph B.
Publicat a PLoS One (2021)

Canonical Wnt/β-catenin Signaling Drives Human Schwann Cell Transformation, Progression, and Tumor Maintenance

per Watson, Adrienne L., Rahrmann, Eric P., Moriarity, Branden S., Choi, Kwangmin, Conboy, Caitlin B., Greeley, Andrew D., Halfond, Amanda L., Anderson, Leah K., Wahl, Brian R., Keng, Vincent W., Rizzardi, Anthony E., Forster, Colleen L., Collins, Margaret H., Sarver, Aaron L., Wallace, Margaret R., Schmechel, Stephen C., Ratner, Nancy, Largaespada, David A.
Publicat 2013

Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1

per Isakson, Sara H., Rizzardi, Anthony E., Coutts, Alexander W., Carlson, Daniel F., Kirstein, Mark N., Fisher, James, Vitte, Jeremie, Williams, Kyle B., Pluhar, G. Elizabeth, Dahiya, Sonika, Widemann, Brigitte C., Dombi, Eva, Rizvi, Tilat, Ratner, Nancy, Messiaen, Ludwine, Stemmer-Rachamimov, Anat O., Fahrenkrug, Scott C., Gutmann, David H., Giovannini, Marco, Moertel, Christopher L., Largaespada, David A., Watson, Adrienne L.
Publicat a Commun Biol (2018)