Identification of candidate neoantigens produced by fusion transcripts in human osteosarcomas

Osteosarcomas are characterized by highly disrupted genomes. Although osteosarcomas lack common fusions, we find evidence of many tumour specific gene-gene fusion transcripts, likely due to chromosomal rearrangements and expression of transcription-induced chimeras. Most of the fusions result in out...

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Udgivet i:Sci Rep
Main Authors: Rathe, Susan K., Popescu, Flavia E., Johnson, James E., Watson, Adrienne L., Marko, Tracy A., Moriarity, Branden S., Ohlfest, John R., Largaespada, David A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344567/
https://ncbi.nlm.nih.gov/pubmed/30674975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36840-z
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