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Identification of candidate neoantigens produced by fusion transcripts in human osteosarcomas

Osteosarcomas are characterized by highly disrupted genomes. Although osteosarcomas lack common fusions, we find evidence of many tumour specific gene-gene fusion transcripts, likely due to chromosomal rearrangements and expression of transcription-induced chimeras. Most of the fusions result in out...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Rathe, Susan K., Popescu, Flavia E., Johnson, James E., Watson, Adrienne L., Marko, Tracy A., Moriarity, Branden S., Ohlfest, John R., Largaespada, David A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344567/
https://ncbi.nlm.nih.gov/pubmed/30674975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36840-z
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