Shared Genetic Contribution of Type 2 Diabetes and Cardiovascular Disease: Implications for Prognosis and Treatment

por Strawbridge, Rona J., van Zuydam, Natalie R.
Publicado en Curr Diab Rep (2018)

A Targeted Sequencing Study to Uncover Shared Genetic Susceptibility between Peripheral Artery Disease and Coronary Heart Disease

por Safarova, Maya S., Fan, Xiao, Austin, Erin E, van Zuydam, Natalie, Hopewell, Jemma, Schaid, Daniel J., Kullo, Iftikhar J.
Publicado en Arterioscler Thromb Vasc Biol (2019)

Genetic variants predicting left ventricular hypertrophy in a diabetic population: a Go-DARTS study including meta-analysis

por Parry, Helen M, Donnelly, Louise A, Van Zuydam, Natalie, Doney, Alexander SF, Elder, Douglas HJ, Morris, Andrew D, Struthers, Alan D, Palmer, Colin NA, Lang, Chim C
Publicado 2013

Both High and Low HbA1c Predict Incident Heart Failure in Type 2 Diabetes Mellitus

por Parry, Helen M., Deshmukh, Harshal, Levin, Daniel, Van Zuydam, Natalie, Elder, Douglas H.J., Morris, Andrew D., Struthers, Allan D., Palmer, Colin N.A., Doney, Alex S.F., Lang, Chim C.
Publicado en Circ Heart Fail (2015)

Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

por Mills, Melinda C., Tropf, Felix C., Brazel, David M., van Zuydam, Natalie, Vaez, Ahmad, Pers, Tune H., Snieder, Harold, Perry, John R.B., Ong, Ken K., den Hoed, Marcel, Barban, Nicola, Day, Felix R.
Publicado en Nat Hum Behav (2021)

Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis

por Zhou, Kaixin, Donnelly, Louise, Yang, Jian, Li, Miaoxin, Deshmukh, Harshal, Van Zuydam, Natalie, Ahlqvist, Emma, Spencer, Chris C, Groop, Leif, Morris, Andrew D, Colhoun, Helen M, Sham, Pak C, McCarthy, Mark I, Palmer, Colin N A, Pearson, Ewan R
Publicado 2014

Robust association of the LPA locus with LDLc lowering response to statin treatment in a meta-analysis of 30,467 individuals from both randomised control trials and observational s...

por Donnelly, Louise A, van Zuydam, Natalie R, Zhou, Kaixin, Tavendale, Roger, Carr, Fiona, Maitland-van der Zee, Anke H, Leusink, Maarten, de Boer, Anthonius, Doevendans, Pieter A, WAsselbergs, Folkert, Morris, Andrew D, Pearson, Ewan R, Klungel, Olaf H, Doney, Alex SF, Palmer, Colin NA
Publicado 2013

Causal relationships between gut microbiome, short-chain fatty acids and metabolic diseases

por Sanna, Serena, van Zuydam, Natalie R., Mahajan, Anubha, Kurilshikov, Alexander, Vila, Arnau Vich, Võsa, Urmo, Mujagic, Zlatan, Masclee, Ad A. M., Jonkers, Daisy M.A.E., Oosting, Marije, Joosten, Leo A.B., Netea, Mihai G., Franke, Lude, Zhernakova, Alexandra, Fu, Jingyuan, Wijmenga, Cisca, McCarthy, Mark I.
Publicado en Nat Genet (2019)

A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes

por Taira, Makiko, Imamura, Minako, Takahashi, Atsushi, Kamatani, Yoichiro, Yamauchi, Toshimasa, Araki, Shin-ichi, Tanaka, Nobue, van Zuydam, Natalie R., Ahlqvist, Emma, Toyoda, Masao, Umezono, Tomoya, Kawai, Koichi, Imanishi, Masahito, Watada, Hirotaka, Suzuki, Daisuke, Maegawa, Hiroshi, Babazono, Tetsuya, Kaku, Kohei, Kawamori, Ryuzo, Groop, Leif C., McCarthy, Mark I., Kadowaki, Takashi, Maeda, Shiro
Publicado en PLoS One (2018)

Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes

por Zabulica, Mihaela, Srinivasan, Raghuraman C., Akcakaya, Pinar, Allegri, Gabriella, Bestas, Burcu, Firth, Mike, Hammarstedt, Christina, Jakobsson, Tomas, Jakobsson, Towe, Ellis, Ewa, Jorns, Carl, Makris, Georgios, Scherer, Tanja, Rimann, Nicole, van Zuydam, Natalie R., Gramignoli, Roberto, Forslöw, Anna, Engberg, Susanna, Maresca, Marcello, Rooyackers, Olav, Thöny, Beat, Häberle, Johannes, Rosen, Barry, Strom, Stephen C.
Publicado en Mol Ther (2021)

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria

por Ahluwalia, Tarunveer S., Schulz, Christina-Alexandra, Waage, Johannes, Skaaby, Tea, Sandholm, Niina, van Zuydam, Natalie, Charmet, Romain, Bork-Jensen, Jette, Almgren, Peter, Thuesen, Betina H., Bedin, Mathilda, Brandslund, Ivan, Christensen, Cramer K., Linneberg, Allan, Ahlqvist, Emma, Groop, Per-Henrik, Hadjadj, Samy, Tregouet, David-Alexandre, Jørgensen, Marit E., Grarup, Niels, Pedersen, Oluf, Simons, Matias, Groop, Leif, Orho-Melander, Marju, McCarthy, Mark I., Melander, Olle, Rossing, Peter, Kilpeläinen, Tuomas O., Hansen, Torben
Publicado en Diabetologia (2018)

Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease

por Persson, Jonas, Strawbridge, Rona J, McLeod, Olga, Gertow, Karl, Silveira, Angela, Baldassarre, Damiano, Van Zuydam, Natalie, Shah, Sonia, Fava, Cristiano, Gustafsson, Stefan, Veglia, Fabrizio, Sennblad, Bengt, Larsson, Malin, Sabater-Lleal, Maria, Leander, Karin, Gigante, Bruna, Tabak, Adam, Kivimaki, Mika, Kauhanen, Jussi, Rauramaa, Rainer, Smit, Andries J, Mannarino, Elmo, Giral, Philippe, Humphries, Steve E, Tremoli, Elena, de Faire, Ulf, Lind, Lars, Ingelsson, Erik, Hedblad, Bo, Melander, Olle, Kumari, Meena, Hingorani, Aroon, Morris, Andrew D, Palmer, Colin N A, Lundman, Pia, Öhrvik, John, Söderberg, Stefan, Hamsten, Anders
Publicado en J Am Heart Assoc (2015)

Candidate Gene Association Study for Diabetic Retinopathy in Persons with Type 2 Diabetes: The Candidate Gene Association Resource (CARe)

por Sobrin, Lucia, Green, Todd, Sim, Xueling, Jensen, Richard A., Tai, E. Shyong, Tay, Wan Ting, Wang, Jie Jin, Mitchell, Paul, Sandholm, Niina, Liu, Yiyuan, Hietala, Kustaa, Iyengar, Sudha K., Brooks, Matthew, Buraczynska, Monika, Van Zuydam, Natalie, Smith, Albert V., Gudnason, Vilmundur, Doney, Alex S. F., Morris, Andrew D., Leese, Graham P., Palmer, Colin N. A., Swaroop, Anand, Taylor, Herman A., Wilson, James G., Penman, Alan, Chen, Ching J., Groop, Per-Henrik, Saw, Seang-Mei, Aung, Tin, Klein, Barbara E., Rotter, Jerome I., Siscovick, David S., Cotch, Mary Frances, Klein, Ronald, Daly, Mark J., Wong, Tien Y.
Publicado 2011

Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity

por Mahajan, Anubha, Rodan, Aylin R., Le, Thu H., Gaulton, Kyle J., Haessler, Jeffrey, Stilp, Adrienne M., Kamatani, Yoichiro, Zhu, Gu, Sofer, Tamar, Puri, Sanjana, Schellinger, Jeffrey N., Chu, Pei-Lun, Cechova, Sylvia, van Zuydam, Natalie, Arnlov, Johan, Flessner, Michael F., Giedraitis, Vilmantas, Heath, Andrew C., Kubo, Michiaki, Larsson, Anders, Lindgren, Cecilia M., Madden, Pamela A.F., Montgomery, Grant W., Papanicolaou, George J., Reiner, Alex P., Sundström, Johan, Thornton, Timothy A., Lind, Lars, Ingelsson, Erik, Cai, Jianwen, Martin, Nicholas G., Kooperberg, Charles, Matsuda, Koichi, Whitfield, John B., Okada, Yukinori, Laurie, Cathy C., Morris, Andrew P., Franceschini, Nora
Publicado en Am J Hum Genet (2016)

The Genetic Landscape of Renal Complications in Type 1 Diabetes

por Sandholm, Niina, Van Zuydam, Natalie, Ahlqvist, Emma, Juliusdottir, Thorhildur, Deshmukh, Harshal A., Rayner, N. William, Di Camillo, Barbara, Forsblom, Carol, Fadista, Joao, Ziemek, Daniel, Salem, Rany M., Hiraki, Linda T., Pezzolesi, Marcus, Trégouët, David, Dahlström, Emma, Valo, Erkka, Oskolkov, Nikolay, Ladenvall, Claes, Marcovecchio, M. Loredana, Cooper, Jason, Sambo, Francesco, Malovini, Alberto, Manfrini, Marco, McKnight, Amy Jayne, Lajer, Maria, Harjutsalo, Valma, Gordin, Daniel, Parkkonen, Maija, Lyssenko, Valeriya, McKeigue, Paul M., Rich, Stephen S., Brosnan, Mary Julia, Fauman, Eric, Bellazzi, Riccardo, Rossing, Peter, Hadjadj, Samy, Krolewski, Andrzej, Paterson, Andrew D., Hirschhorn, Joel N., Maxwell, Alexander P., Cobelli, Claudio, Colhoun, Helen M., Groop, Leif, McCarthy, Mark I., Groop, Per-Henrik
Publicado en J Am Soc Nephrol (2017)

Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus

por van Zuydam, Natalie R., Ladenvall, Claes, Voight, Benjamin F., Strawbridge, Rona J., Fernandez-Tajes, Juan, Rayner, N. William, Robertson, Neil R., Mahajan, Anubha, Vlachopoulou, Efthymia, Goel, Anuj, Kleber, Marcus E., Nelson, Christopher P., Kwee, Lydia Coulter, Esko, Tõnu, Mihailov, Evelin, Mägi, Reedik, Milani, Lili, Fischer, Krista, Kanoni, Stavroula, Kumar, Jitender, Song, Ci, Hartiala, Jaana A., Pedersen, Nancy L., Perola, Markus, Gieger, Christian, Peters, Annette, Qu, Liming, Willems, Sara M., Doney, Alex S.F., Morris, Andrew D., Zheng, Yan, Sesti, Giorgio, Hu, Frank B., Qi, Lu, Laakso, Markku, Thorsteinsdottir, Unnur, Grallert, Harald, van Duijn, Cornelia, Reilly, Muredach P., Ingelsson, Erik, Deloukas, Panos, Kathiresan, Sek, Metspalu, Andres, Shah, Svati H., Sinisalo, Juha, Salomaa, Veikko, Hamsten, Anders, Samani, Nilesh J., März, Winfried, Hazen, Stanley L., Watkins, Hugh, Saleheen, Danish, Morris, Andrew P., Colhoun, Helen M., Groop, Leif, McCarthy, Mark I., Palmer, Colin N.A.
Publicado en Circ Genom Precis Med (2020)

Genetic Loci for Retinal Arteriolar Microcirculation

por Sim, Xueling, Jensen, Richard A., Ikram, M. Kamran, Cotch, Mary Frances, Li, Xiaohui, MacGregor, Stuart, Xie, Jing, Smith, Albert Vernon, Boerwinkle, Eric, Mitchell, Paul, Klein, Ronald, Klein, Barbara E. K., Glazer, Nicole L., Lumley, Thomas, McKnight, Barbara, Psaty, Bruce M., de Jong, Paulus T. V. M., Hofman, Albert, Rivadeneira, Fernando, Uitterlinden, Andre G., van Duijn, Cornelia M., Aspelund, Thor, Eiriksdottir, Gudny, Harris, Tamara B., Jonasson, Fridbert, Launer, Lenore J., Attia, John, Baird, Paul N., Harrap, Stephen, Holliday, Elizabeth G., Inouye, Michael, Rochtchina, Elena, Scott, Rodney J., Viswanathan, Ananth, Li, Guo, Smith, Nicholas L., Wiggins, Kerri L., Kuo, Jane Z., Taylor, Kent D., Hewitt, Alex W., Martin, Nicholas G., Montgomery, Grant W., Sun, Cong, Young, Terri L., Mackey, David A., van Zuydam, Natalie R., Doney, Alex S. F., Palmer, Colin N. A., Morris, Andrew D., Rotter, Jerome I., Tai, E. Shyong, Gudnason, Vilmundur, Vingerling, Johannes R., Siscovick, David S., Wang, Jie Jin, Wong, Tien Y.
Publicado 2013

Loss of Cardio-Protective Effects at the ADAMTS7 Locus Due to Gene-Smoking Interactions

por Saleheen, Danish, Zhao, Wei, Young, Robin, Nelson, Christopher P., Ho, WeangKee, Ferguson, Jane F., Rasheed, Asif, Ou, Kristy, Nurnberg, Sylvia T., Bauer, Robert C., Goel, Anuj, Do, Ron, Stewart, Alexandre F.R., Hartiala, Jaana, Zhang, Weihua, Thorleifsson, Gudmar, Strawbridge, Rona J, Sinisalo, Juha, Kanoni, Stavroula, Sedaghat, Sanaz, Marouli, Eirini, Kristiansson, Kati, Zhao, Jing Hua, Scott, Robert, Gauguier, Dominique, Shah, Svati H., Smith, Albert Vernon, van Zuydam, Natalie, Cox, Amanda J., Willenborg, Christina, Kessler, Thorsten, Zeng, Lingyao, Province, Michael A., Ganna, Andrea, Lind, Lars, Pedersen, Nancy L., White, Charles C., Joensuu, Anni, Kleber, Marcus Edi, Hall, Alistair S., März, Winfried, Salomaa, Veikko, O’Donnell, Christopher, Ingelsson, Erik, Feitosa, Mary F., Erdmann, Jeanette, Bowden, Donald W., Palmer, Colin N.A., Gudnason, Vilmundur, De Faire, Ulf, Zalloua, Pierre, Wareham, Nicholas, Thompson, John R., Kuulasmaa, Kari, Dedoussis, George, Perola, Markus, Dehghan, Abbas, Chambers, John C., Kooner, Jaspal, Allayee, Hooman, Deloukas, Panos, McPherson, Ruth, Stefansson, Kari, Schunkert, Heribert, Kathiresan, Sekar, Farrall, Martin, Frossard, Philippe Marcel, Rader, Daniel J., Samani, Nilesh J., Reilly, Muredach P.
Publicado en Circulation (2017)

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies

por Traylor, Matthew, Farrall, Martin, Holliday, Elizabeth G, Sudlow, Cathie, Hopewell, Jemma C, Cheng, Yu-Ching, Fornage, Myriam, Ikram, M Arfan, Malik, Rainer, Bevan, Steve, Thorsteinsdottir, Unnur, Nalls, Mike A, Longstreth, WT, Wiggins, Kerri L, Yadav, Sunaina, Parati, Eugenio A, DeStefano, Anita L, Worrall, Bradford B, Kittner, Steven J, Khan, Muhammad Saleem, Reiner, Alex P, Helgadottir, Anna, Achterberg, Sefanja, Fernandez-Cadenas, Israel, Abboud, Sherine, Schmidt, Reinhold, Walters, Matthew, Chen, Wei-Min, Ringelstein, E Bernd, O'Donnell, Martin, Ho, Weang Kee, Pera, Joanna, Lemmens, Robin, Norrving, Bo, Higgins, Peter, Benn, Marianne, Sale, Michele, Kuhlenbäumer, Gregor, Doney, Alexander S F, Vicente, Astrid M, Delavaran, Hossein, Algra, Ale, Davies, Gail, Oliveira, Sofia A, Palmer, Colin N A, Deary, Ian, Schmidt, Helena, Pandolfo, Massimo, Montaner, Joan, Carty, Cara, de Bakker, Paul I W, Kostulas, Konstantinos, Ferro, Jose M, van Zuydam, Natalie R, Valdimarsson, Einar, Nordestgaard, Børge G, Lindgren, Arne, Thijs, Vincent, Slowik, Agnieszka, Saleheen, Danish, Paré, Guillaume, Berger, Klaus, Thorleifsson, Gudmar, Hofman, Albert, Mosley, Thomas H, Mitchell, Braxton D, Furie, Karen, Clarke, Robert, Levi, Christopher, Seshadri, Sudha, Gschwendtner, Andreas, Boncoraglio, Giorgio B, Sharma, Pankaj, Bis, Joshua C, Gretarsdottir, Solveig, Psaty, Bruce M, Rothwell, Peter M, Rosand, Jonathan, Meschia, James F, Stefansson, Kari, Dichgans, Martin, Markus, Hugh S
Publicado 2012

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

por van Zuydam, Natalie R., Ahlqvist, Emma, Sandholm, Niina, Deshmukh, Harshal, Rayner, N. William, Abdalla, Moustafa, Ladenvall, Claes, Ziemek, Daniel, Fauman, Eric, Robertson, Neil R., McKeigue, Paul M., Valo, Erkka, Forsblom, Carol, Harjutsalo, Valma, Perna, Annalisa, Rurali, Erica, Marcovecchio, M. Loredana, Igo, Robert P., Salem, Rany M., Perico, Norberto, Lajer, Maria, Käräjämäki, Annemari, Imamura, Minako, Kubo, Michiaki, Takahashi, Atsushi, Sim, Xueling, Liu, Jianjun, van Dam, Rob M., Jiang, Guozhi, Tam, Claudia H.T., Luk, Andrea O.Y., Lee, Heung Man, Lim, Cadmon K.P., Szeto, Cheuk Chun, So, Wing Yee, Chan, Juliana C.N., Ang, Su Fen, Dorajoo, Rajkumar, Wang, Ling, Clara, Tan Si Hua, McKnight, Amy-Jayne, Duffy, Seamus, Pezzolesi, Marcus G., Marre, Michel, Gyorgy, Beata, Hadjadj, Samy, Hiraki, Linda T., Ahluwalia, Tarunveer S., Almgren, Peter, Schulz, Christina-Alexandra, Orho-Melander, Marju, Linneberg, Allan, Christensen, Cramer, Witte, Daniel R., Grarup, Niels, Brandslund, Ivan, Melander, Olle, Paterson, Andrew D., Tregouet, David, Maxwell, Alexander P., Lim, Su Chi, Ma, Ronald C.W., Tai, E Shyong, Maeda, Shiro, Lyssenko, Valeriya, Tuomi, Tiinamaija, Krolewski, Andrzej S., Rich, Stephen S., Hirschhorn, Joel N., Florez, Jose C., Dunger, David, Pedersen, Oluf, Hansen, Torben, Rossing, Peter, Remuzzi, Giuseppe, Brosnan, Mary Julia, Palmer, Colin N.A., Groop, Per-Henrik, Colhoun, Helen M., Groop, Leif C., McCarthy, Mark I.
Publicado en Diabetes (2018)