Robust association of the LPA locus with LDLc lowering response to statin treatment in a meta-analysis of 30,467 individuals from both randomised control trials and observational studies and association with coronary artery disease outcome during statin treatment

OBJECTIVES: The LPA SNP rs10455872 has been associated with low density lipoprotein cholesterol (LDLc) lowering response to statins in several randomised control trials (RCTs) and is a known coronary artery disease (CAD) marker. However it is unclear what residual risk of CAD this marker may have du...

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Main Authors: Donnelly, Louise A, van Zuydam, Natalie R, Zhou, Kaixin, Tavendale, Roger, Carr, Fiona, Maitland-van der Zee, Anke H, Leusink, Maarten, de Boer, Anthonius, Doevendans, Pieter A, WAsselbergs, Folkert, Morris, Andrew D, Pearson, Ewan R, Klungel, Olaf H, Doney, Alex SF, Palmer, Colin NA
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110714/
https://ncbi.nlm.nih.gov/pubmed/23903772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e3283642fd6
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