Reconstruction of a pathway of antigen processing and class II MHC peptide capture

per Moss, Catherine X, Tree, Timothy I, Watts, Colin
Publicat 2007

Regulatory T cell dysfunction in type 1 diabetes: what’s broken and how can we fix it?

per Hull, Caroline M., Peakman, Mark, Tree, Timothy I. M.
Publicat a Diabetologia (2017)

HLA Class II molecules on haplotypes associated with type 1 diabetes exhibit similar patterns of binding affinities for coxsackievirus P2C peptides

per Ellis, Richard J, Varela-Calvino, Ruben, Tree, Timothy I M, Peakman, Mark
Publicat 2005

Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

per Tree, Timothy I.M., Lawson, Jennifer, Edwards, Hannah, Skowera, Ania, Arif, Sefina, Roep, Bart O., Peakman, Mark
Publicat 2010

Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

per Arif, Sefina, Tree, Timothy I., Astill, Thomas P., Tremble, Jennifer M., Bishop, Amanda J., Dayan, Colin M., Roep, Bart O., Peakman, Mark
Publicat 2004

Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances

per Ahmed, Simi, Cerosaletti, Karen, James, Eddie, Long, S. Alice, Mannering, Stuart, Speake, Cate, Nakayama, Maki, Tree, Timothy, Roep, Bart O., Herold, Kevan C., Brusko, Todd M.
Publicat a Diabetes (2019)

Multipotent Adult Progenitor Cells Suppress T Cell Activation in In Vivo Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner

per Carty, Fiona, Corbett, Jennifer M., Cunha, João Paulo M. C. M., Reading, James L., Tree, Timothy I. M., Ting, Anthony E., Stubblefield, Samantha R., English, Karen
Publicat a Front Immunol (2018)

Mapping T Cell Responses to Native and Neo-Islet Antigen Epitopes in at Risk and Type 1 Diabetes Subjects

per Arif, Sefina, Pujol-Autonell, Irma, Kamra, Yogesh, Williams, Evangelia, Yusuf, Norkhairin, Domingo-Vila, Clara, Shahrabi, Yasaman, Pollock, Emily, Khatri, Leena, Peakman, Mark, Tree, Timothy, Lorenc, Anna
Publicat a Front Immunol (2021)

Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture

per Allen, Jennifer S., Pang, Karl, Skowera, Ania, Ellis, Richard, Rackham, Chloe, Lozanoska-Ochser, Biliana, Tree, Timothy, Leslie, R. David G., Tremble, Jennifer M., Dayan, Colin M., Peakman, Mark
Publicat 2009

GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 autoreactive CD4 T cells

per Arif, Sefina, Gomez-Tourino, Iria, Kamra, Yogesh, Pujol-Autonell, Irma, Hanton, Emily, Tree, Timothy, Melandri, Daisy, Hull, Caroline, Wherrett, Diane K., Beam, Craig, Roep, Bart O., Lorenc, Anna, Peakman, Mark
Publicat a Diabetologia (2020)

Type 1 Diabetes-associated IL2RAvariationlowers IL-2 signaling and contributes to diminished CD4(+)CD25(+) regulatory T-cell function

per Garg, Garima, Tyler, Jennifer R, Yang, Jennie H M, Cutler, Antony J, Downes, Kate, Pekalski, Marcin, Bell, Louise, Nutland, Sarah, Peakman, Mark, Todd, John A, Wicker, Linda S, Tree, Timothy I M
Publicat 2012

Systemic inflammatory response and neuromuscular involvement in amyotrophic lateral sclerosis

per Lu, Ching-Hua, Allen, Kezia, Oei, Felicia, Leoni, Emanuela, Kuhle, Jens, Tree, Timothy, Fratta, Pietro, Sharma, Nikhil, Sidle, Katie, Howard, Robin, Orrell, Richard, Fish, Mark, Greensmith, Linda, Pearce, Neil, Gallo, Valentina, Malaspina, Andrea
Publicat a Neurol Neuroimmunol Neuroinflamm (2016)

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death

per Arif, Sefina, Moore, Fabrice, Marks, Katherine, Bouckenooghe, Thomas, Dayan, Colin M., Planas, Raquel, Vives-Pi, Marta, Powrie, Jake, Tree, Timothy, Marchetti, Piero, Huang, Guo Cai, Gurzov, Esteban N., Pujol-Borrell, Ricardo, Eizirik, Decio L., Peakman, Mark
Publicat 2011

IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors

per Whitehouse, Gavin, Gray, Elizabeth, Mastoridis, Sotiris, Merritt, Elliot, Kodela, Elisavet, Yang, Jennie H. M., Danger, Richard, Mairal, Marta, Christakoudi, Sofia, Lozano, Juan J., Macdougall, Iain C., Tree, Timothy I. M., Sanchez-Fueyo, Alberto, Martinez-Llordella, Marc
Publicat a Proc Natl Acad Sci U S A (2017)

Suppression of IL-7-dependent Effector T-cell Expansion by Multipotent Adult Progenitor Cells and PGE2

per Reading, James L, Vaes, Bart, Hull, Caroline, Sabbah, Shereen, Hayday, Thomas, Wang, Nancy S, DiPiero, Anthony, Lehman, Nicholas A, Taggart, Jen M, Carty, Fiona, English, Karen, Pinxteren, Jef, Deans, Robert, Ting, Anthony E, Tree, Timothy I M
Publicat a Mol Ther (2015)

Natural variation in IL-2 sensitivity influences regulatory T cell frequency and function in individuals with long-standing type 1 diabetes

per Yang, Jennie H.M., Cutler, Antony J., Ferreira, Ricardo C., Reading, James L., Cooper, Nicholas J., Wallace, Chris, Clarke, Pamela, Smyth, Deborah J., Boyce, Christopher S., Gao, Guo-Jian, Todd, John A., Wicker, Linda S., Tree, Timothy I.M.
Publicat a Diabetes (2015)

Type 1 diabetes can present before the age of 6 months and is characterised by autoimmunity and rapid loss of beta cells

per Johnson, Matthew B., Patel, Kashyap A., De Franco, Elisa, Hagopian, William, Killian, Michael, McDonald, Timothy J., Tree, Timothy I. M., Domingo-Vila, Clara, Hudson, Michelle, Hammersley, Suzanne, Dobbs, Rebecca, Ellard, Sian, Flanagan, Sarah E., Hattersley, Andrew T., Oram, Richard A.
Publicat a Diabetologia (2020)

Boosting of Waned Humoral and Cellular Responses to SARS-CoV-2 Variants of Concern Among Patients with Cancer

per McKenzie, Duncan R., Graham, Rosalind, Lechmere, Thomas, Domingo-Vila, Clara, Alaguthurai, Thanussuyah, Arman, Celeste, Pollock, Emily, Gousis, Charalampos, Kakkassery, Helen, Carpenter, Esme, Kurshan, Ashwini, Vidler, Jennifer, Kulasekararaj, Austin, Patten, Piers, North, Bernard V., Tree, Timothy, Doores, Katie J., Hayday, Adrian C., Irshad, Sheeba
Publicat a Cancer Res Commun (2022)

CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

per Skowera, Ania, Ellis, Richard J., Varela-Calviño, Ruben, Arif, Sefina, Huang, Guo Cai, Van-Krinks, Cassie, Zaremba, Anna, Rackham, Chloe, Allen, Jennifer S., Tree, Timothy I.M., Zhao, Min, Dayan, Colin M., Sewell, Andrew K., Unger, Wendy, Drijfhout, Jan W., Ossendorp, Ferry, Roep, Bart O., Peakman, Mark
Publicat 2008

CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

per Skowera, Ania, Ellis, Richard J., Varela-Calviño, Ruben, Arif, Sefina, Huang, Guo Cai, Van-Krinks, Cassie, Zaremba, Anna, Rackham, Chloe, Allen, Jennifer S., Tree, Timothy I.M., Zhao, Min, Dayan, Colin M., Sewell, Andrew K., Unger, Wendy W., Drijfhout, Jan W., Ossendorp, Ferry, Roep, Bart O., Peakman, Mark
Publicat 2009