CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

The final pathway of β cell destruction leading to insulin deficiency, hyperglycemia, and clinical type 1 diabetes is unknown. Here we show that circulating CTLs can kill β cells via recognition of a glucose-regulated epitope. First, we identified 2 naturally processed epitopes from the human prepro...

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Hlavní autoři: Skowera, Ania, Ellis, Richard J., Varela-Calviño, Ruben, Arif, Sefina, Huang, Guo Cai, Van-Krinks, Cassie, Zaremba, Anna, Rackham, Chloe, Allen, Jennifer S., Tree, Timothy I.M., Zhao, Min, Dayan, Colin M., Sewell, Andrew K., Unger, Wendy, Drijfhout, Jan W., Ossendorp, Ferry, Roep, Bart O., Peakman, Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2008
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542849/
https://ncbi.nlm.nih.gov/pubmed/18802479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35449
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