Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity

The end-stage immunopathology of type 1 diabetes resulting in β-cell destruction appears to be strongly dominated by cytotoxic CD8 T lymphocytes (CD8 T cells). However, the mechanism of cytotoxicity used by autoreactive CD8 T cells in the human setting remains unknown. Using type 1 diabetes patient–...

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Main Authors: Knight, Robin R., Kronenberg, Deborah, Zhao, Min, Huang, Guo Cai, Eichmann, Martin, Bulek, Anna, Wooldridge, Linda, Cole, David K., Sewell, Andrew K., Peakman, Mark, Skowera, Ania
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Diabetes Association 2013
Ábhair:
Immunology and Transplantation
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526019/
https://ncbi.nlm.nih.gov/pubmed/22936177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0315
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