Circulating Preproinsulin Signal Peptide–Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill β-Cells

Type 1 diabetes results from T cell–mediated β-cell destruction. The HLA-A*24 class I gene confers significant risk of disease and early onset. We tested the hypothesis that HLA-A24 molecules on islet cells present preproinsulin (PPI) peptide epitopes to CD8 cytotoxic T cells (CTLs). Surrogate β-cel...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Kronenberg, Deborah, Knight, Robin R., Estorninho, Megan, Ellis, Richard J., Kester, Michel G., de Ru, Arnoud, Eichmann, Martin, Huang, Guo C., Powrie, Jake, Dayan, Colin M., Skowera, Ania, van Veelen, Peter A., Peakman, Mark
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Diabetes Association 2012
Aiheet:
Immunology and Transplantation
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379678/
https://ncbi.nlm.nih.gov/pubmed/22522618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1520
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia