Circulating Preproinsulin Signal Peptide–Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill β-Cells

Type 1 diabetes results from T cell–mediated β-cell destruction. The HLA-A*24 class I gene confers significant risk of disease and early onset. We tested the hypothesis that HLA-A24 molecules on islet cells present preproinsulin (PPI) peptide epitopes to CD8 cytotoxic T cells (CTLs). Surrogate β-cel...

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Detalhes bibliográficos
Main Authors: Kronenberg, Deborah, Knight, Robin R., Estorninho, Megan, Ellis, Richard J., Kester, Michel G., de Ru, Arnoud, Eichmann, Martin, Huang, Guo C., Powrie, Jake, Dayan, Colin M., Skowera, Ania, van Veelen, Peter A., Peakman, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2012
Assuntos:
Immunology and Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379678/
https://ncbi.nlm.nih.gov/pubmed/22522618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1520
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