Circulating Preproinsulin Signal Peptide–Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill β-Cells

Type 1 diabetes results from T cell–mediated β-cell destruction. The HLA-A*24 class I gene confers significant risk of disease and early onset. We tested the hypothesis that HLA-A24 molecules on islet cells present preproinsulin (PPI) peptide epitopes to CD8 cytotoxic T cells (CTLs). Surrogate β-cel...

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Main Authors: Kronenberg, Deborah, Knight, Robin R., Estorninho, Megan, Ellis, Richard J., Kester, Michel G., de Ru, Arnoud, Eichmann, Martin, Huang, Guo C., Powrie, Jake, Dayan, Colin M., Skowera, Ania, van Veelen, Peter A., Peakman, Mark
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Diabetes Association 2012
Ábhair:
Immunology and Transplantation
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379678/
https://ncbi.nlm.nih.gov/pubmed/22522618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1520
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