Type 1 Diabetes-associated IL2RAvariationlowers IL-2 signaling and contributes to diminished CD4(+)CD25(+) regulatory T-cell function

Por Garg, Garima, Tyler, Jennifer R, Yang, Jennie H M, Cutler, Antony J, Downes, Kate, Pekalski, Marcin, Bell, Louise, Nutland, Sarah, Peakman, Mark, Todd, John A, Wicker, Linda S, Tree, Timothy I M
Publicado em 2012

Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes

Por Bailey, Rebecca, Cooper, Jason D., Zeitels, Lauren, Smyth, Deborah J., Yang, Jennie H.M., Walker, Neil M., Hyppönen, Elina, Dunger, David B., Ramos-Lopez, Elizabeth, Badenhoop, Klaus, Nejentsev, Sergey, Todd, John A.
Publicado em 2007

Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes

Por Wallace, Chris, Rotival, Maxime, Cooper, Jason D., Rice, Catherine M., Yang, Jennie H.M., McNeill, Mhairi, Smyth, Deborah J., Niblett, David, Cambien, François, Tiret, Laurence, Todd, John A., Clayton, David G., Blankenberg, Stefan
Publicado em 2012

IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors

Por Whitehouse, Gavin, Gray, Elizabeth, Mastoridis, Sotiris, Merritt, Elliot, Kodela, Elisavet, Yang, Jennie H. M., Danger, Richard, Mairal, Marta, Christakoudi, Sofia, Lozano, Juan J., Macdougall, Iain C., Tree, Timothy I. M., Sanchez-Fueyo, Alberto, Martinez-Llordella, Marc
Publicado no Proc Natl Acad Sci U S A (2017)

Natural variation in IL-2 sensitivity influences regulatory T cell frequency and function in individuals with long-standing type 1 diabetes

Por Yang, Jennie H.M., Cutler, Antony J., Ferreira, Ricardo C., Reading, James L., Cooper, Nicholas J., Wallace, Chris, Clarke, Pamela, Smyth, Deborah J., Boyce, Christopher S., Gao, Guo-Jian, Todd, John A., Wicker, Linda S., Tree, Timothy I.M.
Publicado no Diabetes (2015)

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

Por Dendrou, Calliope A., Plagnol, Vincent, Fung, Erik, Yang, Jennie H. M., Downes, Kate, Cooper, Jason D., Nutland, Sarah, Coleman, Gillian, Himsworth, Matthew, Hardy, Matthew, Burren, Oliver, Healy, Barry, Walker, Neil M., Koch, Kerstin, Ouwehand, Willem H., Bradley, John R., Wareham, Nicholas J., Todd, John A., Wicker, Linda S.
Publicado em 2009

Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing

Por Heap, Graham A., Yang, Jennie H.M., Downes, Kate, Healy, Barry C., Hunt, Karen A., Bockett, Nicholas, Franke, Lude, Dubois, Patrick C., Mein, Charles A., Dobson, Richard J., Albert, Thomas J., Rodesch, Matthew J., Clayton, David G., Todd, John A., van Heel, David A., Plagnol, Vincent
Publicado em 2010

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

Por Todd, John A, Walker, Neil M, Cooper, Jason D, Smyth, Deborah J, Downes, Kate, Plagnol, Vincent, Bailey, Rebecca, Nejentsev, Sergey, Field, Sarah F, Payne, Felicity, Lowe, Christopher E, Szeszko, Jeffrey S, Hafler, Jason P, Zeitels, Lauren, Yang, Jennie H M, Vella, Adrian, Nutland, Sarah, Stevens, Helen E, Schuilenburg, Helen, Coleman, Gillian, Maisuria, Meeta, Meadows, William, Smink, Luc J, Healy, Barry, Burren, Oliver S, Lam, Alex A C, Ovington, Nigel R, Allen, James, Adlem, Ellen, Leung, Hin-Tak, Wallace, Chris, Howson, Joanna M M, Guja, Cristian, Ionescu-Tirgoviste, Constantin, Simmonds, Matthew J, Heward, Joanne M, Gough, Stephen CL, Dunger, David B, Wicker, Linda S, Clayton, David G
Publicado em 2007