Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors

Por Seganish, W. Michael, Fischmann, Thierry O., Sherborne, Brad, Matasi, Julius, Lavey, Brian, McElroy, William T., Tulshian, Deen, Tata, James, Sondey, Christopher, Garlisi, Charles G., Devito, Kristine, Fossetta, James, Lundell, Daniel, Niu, Xiaoda
Publicado no ACS Med Chem Lett (2015)

Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation

Por McElroy, William T., Tan, Zheng, Ho, Ginny, Paliwal, Sunil, Li, Guoqing, Seganish, W. Michael, Tulshian, Deen, Tata, James, Fischmann, Thierry O., Sondey, Christopher, Bian, Hong, Bober, Loretta, Jackson, James, Garlisi, Charles G., Devito, Kristine, Fossetta, James, Lundell, Daniel, Niu, Xiaoda
Publicado no ACS Med Chem Lett (2015)

Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension

Por Petrilli, Whitney L., Hoyt, Scott B., London, Clare, McMasters, Daniel, Verras, Andreas, Struthers, Mary, Cully, Doris, Wisniewski, Thomas, Ren, Ning, Bopp, Charlene, Sok, Andrea, Chen, Qing, Li, Ying, Tung, Elaine, Tang, Wei, Salituro, Gino, Knemeyer, Ian, Karanam, Bindhu, Clemas, Joseph, Zhou, Gaochao, Gibson, Jack, Shipley, Carrie Ann, MacNeil, Douglas J., Duffy, Ruth, Tata, James R., Ujjainwalla, Feroze, Ali, Amjad, Xiong, Yusheng
Publicado no ACS Med Chem Lett (2016)

Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists

Por Cox, Jason M., Chu, Hong D., Chelliah, Mariappan V., Debenham, John S., Eagen, Keith, Lan, Ping, Lombardo, Matthew, London, Clare, Plotkin, Michael A., Shah, Unmesh, Sun, Zhongxiang, Vaccaro, Henry M., Venkatraman, Srikanth, Suzuki, Takao, Wang, Nengxue, Ashley, Eric R., Crespo, Alejandro, Madeira, Maria, Leung, Dennis H., Alleyne, Candice, Ogawa, Aimie M., Souza, Sarah, Thomas-Fowlkes, Brande, Di Salvo, Jerry, Weinglass, Adam, Kirkland, Melissa, Pachanski, Michele, Powles, Mary Ann, Tozzo, Effie, Akiyama, Taro E., Ujjainwalla, Feroze, Tata, James R., Sinz, Christopher J.
Publicado no ACS Med Chem Lett (2016)