Examining Crosstalk among Transforming Growth Factor β, Bone Morphogenetic Protein, and Wnt Pathways

Por Coster, Adam D., Thorne, Curtis A., Wu, Lani F., Altschuler, Steven J.
Publicado no J Biol Chem (2017)

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of β-catenin

Por Cselenyi, Christopher S., Jernigan, Kristin K., Tahinci, Emilios, Thorne, Curtis A., Lee, Laura A., Lee, Ethan
Publicado em 2008

Pyrvinium, a Potent Small Molecule Wnt Inhibitor, Promotes Wound Repair and Post-MI Cardiac Remodeling

Por Saraswati, Sarika, Alfaro, Maria P., Thorne, Curtis A., Atkinson, James, Lee, Ethan, Young, Pampee P.
Publicado em 2010

Screening for small molecule inhibitors of embryonic pathways: Sometimes you gotta crack a few eggs

Por Hang, Brian I., Thorne, Curtis A., Robbins, David J., Huppert, Stacey S., Lee, Laura A., Lee, Ethan
Publicado em 2011

Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase

Por Wang, Zhenghan, Tacchelly-Benites, Ofelia, Yang, Eungi, Thorne, Curtis A., Nojima, Hisashi, Lee, Ethan, Ahmed, Yashi
Publicado no Genetics (2016)

GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors

Por Thorne, Curtis A., Wichaidit, Chonlarat, Coster, Adam D., Posner, Bruce A., Wu, Lani F., Altschuler, Steven J.
Publicado no Nat Chem Biol (2014)

sFRP2 Suppression of Bone Morphogenic Protein (BMP) and Wnt Signaling Mediates Mesenchymal Stem Cell (MSC) Self-renewal Promoting Engraftment and Myocardial Repair

Por Alfaro, Maria P., Vincent, Alicia, Saraswati, Sarika, Thorne, Curtis A., Hong, Charles C., Lee, Ethan, Young, Pampee P.
Publicado em 2010

The way Wnt works: Components and mechanism

Por SAITO-DIAZ, KENYI, CHEN, TONY W., WANG, XIAOXI, THORNE, CURTIS A., WALLACE, HEATHER A., PAGE-MCCAW, ANDREA, LEE, ETHAN
Publicado em 2012

Lrp6 is required for convergent extension during Xenopus gastrulation

Por Tahinci, Emilios, Thorne, Curtis A., Franklin, Jeffrey L., Salic, Adrian, Christian, Kelly M., Lee, Laura A., Coffey, Robert J., Lee, Ethan
Publicado no Development (2007)

FGF21 is an Exocrine Pancreas Secretagogue

Por Coate, Katie C., Hernandez, Genaro, Thorne, Curtis A., Sun, Shengyi, Le, Thao D. V., Vale, Kevin, Kliewer, Steven A., Mangelsdorf, David J.
Publicado no Cell Metab (2017)

Selective Small Molecule Targeting β-Catenin Function Discovered by In Vivo Chemical Genetic Screen

Por Hao, Jijun, Ao, Ada, Zhou, Li, Murphy, Clare K., Frist, Audrey Y., Keel, Jessica J., Thorne, Curtis A., Kim, Kwangho, Lee, Ethan, Hong, Charles C.
Publicado em 2013

Gβγ Activates GSK3 to Promote LRP6-Mediated β-Catenin Transcriptional Activity

Por Jernigan, Kristin K., Cselenyi, Christopher S., Thorne, Curtis A., Hanson, Alison J., Tahinci, Emilios, Hajicek, Nicole, Oldham, William M., Lee, Laura A., Hamm, Heidi E., Hepler, John R., Kozasa, Tohru, Linder, Maurine E., Lee, Ethan
Publicado em 2010

A Biochemical Screen for Identification of Small-Molecule Regulators of the Wnt Pathway Using Xenopus Egg Extracts

Por Thorne, Curtis A., Lafleur, Bonnie, Lewis, Michelle, Hanson, Alison J., Jernigan, Kristin K., Weaver, David C., Huppert, Kari A., Chen, Tony W., Wichadiit, Chonlarat, Cselenyi, Christopher S., Tahinci, Emilios, Meyers, Kelly C., Waskow, Emily, Orton, Darren, Salic, Adrian, Lee, Laura A., Robbins, David J., Huppert, Stacey S., Lee, Ethan
Publicado em 2011

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

Por Thorne, Curtis A, Hanson, Alison J, Schneider, Judsen, Tahinci, Emilios, Orton, Darren, Cselenyi, Christopher S, Jernigan, Kristin K, Meyers, Kelly C, Hang, Brian I, Waterson, Alex G, Kim, Kwangho, Melancon, Bruce, Ghidu, Victor P, Sulikowski, Gary A, LaFleur, Bonnie, Salic, Adrian, Lee, Laura A, Miller, David M, Lee, Ethan
Publicado em 2010