Gβγ Activates GSK3 to Promote LRP6-Mediated β-Catenin Transcriptional Activity

Evidence from Drosophila and cultured cell studies support a role for heterotrimeric G proteins in Wnt signaling. Wnt inhibits the degradation of the transcriptional regulator β-catenin. We screened the α subunits of major families of recombinant G protein subunits and Gβγ subunits in a Xenopus egg...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jernigan, Kristin K., Cselenyi, Christopher S., Thorne, Curtis A., Hanson, Alison J., Tahinci, Emilios, Hajicek, Nicole, Oldham, William M., Lee, Laura A., Hamm, Heidi E., Hepler, John R., Kozasa, Tohru, Linder, Maurine E., Lee, Ethan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088111/
https://ncbi.nlm.nih.gov/pubmed/20460648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000647
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