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Gβγ Activates GSK3 to Promote LRP6-Mediated β-Catenin Transcriptional Activity

Evidence from Drosophila and cultured cell studies support a role for heterotrimeric G proteins in Wnt signaling. Wnt inhibits the degradation of the transcriptional regulator β-catenin. We screened the α subunits of major families of recombinant G protein subunits and Gβγ subunits in a Xenopus egg...

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Detalhes bibliográficos
Main Authors: Jernigan, Kristin K., Cselenyi, Christopher S., Thorne, Curtis A., Hanson, Alison J., Tahinci, Emilios, Hajicek, Nicole, Oldham, William M., Lee, Laura A., Hamm, Heidi E., Hepler, John R., Kozasa, Tohru, Linder, Maurine E., Lee, Ethan
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088111/
https://ncbi.nlm.nih.gov/pubmed/20460648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000647
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