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LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of β-catenin

Wnt/β-catenin signaling controls various cell fates in metazoan development and is misregulated in several cancers and developmental disorders. Binding of a Wnt ligand to its transmembrane coreceptors inhibits phosphorylation and degradation of the transcriptional coactivator β-catenin, which then t...

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書誌詳細
主要な著者: Cselenyi, Christopher S., Jernigan, Kristin K., Tahinci, Emilios, Thorne, Curtis A., Lee, Laura A., Lee, Ethan
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430354/
https://ncbi.nlm.nih.gov/pubmed/18509060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803025105
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