Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

Wnt/β-catenin signaling plays a central role in development and is also involved in a diverse array of diseases. Binding of Wnts to the coreceptors Frizzled and LRP6/5 leads to phosphorylation of PPPSPxS motifs in the LRP6/5 intracellular region and the inhibition of GSK3β bound to the scaffold prot...

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Autori principali: Piao, Shunfu, Lee, Sun-Hye, Kim, Hyunjoon, Yum, Soohwan, Stamos, Jennifer L., Xu, Yongbin, Lee, Su-Jin, Lee, Jaewon, Oh, Sangtaek, Han, Jin-Kwan, Park, Bum-Joon, Weis, William I., Ha, Nam-Chul
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603313/
https://ncbi.nlm.nih.gov/pubmed/19107203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004046
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