Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6

Glycogen synthase kinase-3 (GSK-3) is a key regulator of many cellular signaling pathways. Unlike most kinases, GSK-3 is controlled by inhibition rather than by specific activation. In the insulin and several other signaling pathways, phosphorylation of a serine present in a conserved sequence near...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Stamos, Jennifer L, Chu, Matthew Ling-Hon, Enos, Michael D, Shah, Niket, Weis, William I
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2014
Pynciau:
Biochemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953950/
https://ncbi.nlm.nih.gov/pubmed/24642411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01998
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg