Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6

LDL receptor-related proteins 5 and 6 (LRP5/6) are co-receptors for Wnt growth factors, and also bind Dkk proteins, secreted inhibitors of Wnt signaling. The LRP5/6 ectodomain contains four β-propeller/EGF-like domain repeats. The first two repeats (LRP6(1-2)) bind to several Wnt variants, whereas L...

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Main Authors: Ahn, Victoria E., Chu, Matthew Ling-Hon, Choi, Hee-Jung, Tran, Denise, Abo, Arie, Weis, William I.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215855/
https://ncbi.nlm.nih.gov/pubmed/22000856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.09.003
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