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Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6
LDL receptor-related proteins 5 and 6 (LRP5/6) are co-receptors for Wnt growth factors, and also bind Dkk proteins, secreted inhibitors of Wnt signaling. The LRP5/6 ectodomain contains four β-propeller/EGF-like domain repeats. The first two repeats (LRP6(1-2)) bind to several Wnt variants, whereas L...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3215855/ https://ncbi.nlm.nih.gov/pubmed/22000856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.09.003 |
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