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Regulation of Wnt/LRP Signaling by Distinct Domains of Dickkopf Proteins
Dickkopfs (Dkks) are secreted developmental regulators composed of two cysteine-rich domains. We report that the effects of Dkks depend on molecular context. Although Wnt8 signaling is inhibited by both Dkk1 and Dkk2 in Xenopus embryos, the same pathway is activated upon interaction of Dkk2 with the...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC133995/ https://ncbi.nlm.nih.gov/pubmed/12167704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.17.6100-6110.2002 |
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