Regulation of Wnt/LRP Signaling by Distinct Domains of Dickkopf Proteins

Dickkopfs (Dkks) are secreted developmental regulators composed of two cysteine-rich domains. We report that the effects of Dkks depend on molecular context. Although Wnt8 signaling is inhibited by both Dkk1 and Dkk2 in Xenopus embryos, the same pathway is activated upon interaction of Dkk2 with the...

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Publicado en:	Mol Cell Biol
Autores principales:	Brott, Barbara K., Sokol, Sergei Y.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 2002
Materias:	Cell Growth and Development
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133995/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12167704/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.17.6100-6110.2002
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