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Regulation of Wnt/LRP Signaling by Distinct Domains of Dickkopf Proteins

Dickkopfs (Dkks) are secreted developmental regulators composed of two cysteine-rich domains. We report that the effects of Dkks depend on molecular context. Although Wnt8 signaling is inhibited by both Dkk1 and Dkk2 in Xenopus embryos, the same pathway is activated upon interaction of Dkk2 with the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Biol
Prif Awduron: Brott, Barbara K., Sokol, Sergei Y.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2002
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133995/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12167704/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.17.6100-6110.2002
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