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Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6

Wnt/β-catenin signaling is initiated at the cell surface by association of secreted Wnt with its receptors Frizzled (Fz) and low density lipoprotein receptor-related protein 5/6 (LRP5/6). The study of these molecular interactions has been a significant technical challenge because the proteins have b...

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Detalhes bibliográficos
Main Authors: Bourhis, Eric, Tam, Christine, Franke, Yvonne, Bazan, J. Fernando, Ernst, James, Hwang, Jiyoung, Costa, Mike, Cochran, Andrea G., Hannoush, Rami N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838336/
https://ncbi.nlm.nih.gov/pubmed/20093360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.092130
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