Oligomerization of Frizzled and LRP5/6 protein initiates intracellular signaling for the canonical WNT/β-catenin pathway

Upon binding to the canonical WNT glycoproteins, Frizzled family receptors (FZDs) and low-density lipoprotein receptor-related protein 5/6 (LRP5/6) undergo a series of polymerizations on the cell surface that elicit canonical WNT/β-catenin signaling. The hyperactivation of WNT/β-catenin signaling is...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Hua, Yue, Yang, Yilin, Li, Qian, He, Xinyu, Zhu, Wei, Wang, Jiyong, Gan, Xiaoqing
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314125/
https://ncbi.nlm.nih.gov/pubmed/30361437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004434
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