G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway

Wnt ligands conduct their functions in canonical Wnt signaling by binding to two receptors, the single transmembrane low density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) and seven transmembrane (7TM) Frizzled receptors. Subsequently, phosphorylation of serine/threonine residues within...

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Autores principales: Chen, Minyong, Philipp, Melanie, Wang, Jiangbo, Premont, Richard T., Garrison, Tiffany R., Caron, Marc G., Lefkowitz, Robert J., Chen, Wei
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787365/
https://ncbi.nlm.nih.gov/pubmed/19801552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.047456
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