Agonist Dose-dependent Phosphorylation by Protein Kinase A and G Protein-coupled Receptor Kinase Regulates β(2) Adrenoceptor Coupling to G(i) Proteins in Cardiomyocytes

Adrenoceptors receptors (ARs) play a pivotal role in regulating cardiovascular response to catecholamines during stress. β(2)ARs, prototypical G protein-coupled receptors (GPCRs), expressed in animal hearts, display dual coupling to both G(s) and G(i) proteins to control the adenylyl cyclase-cAMP de...

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Bibliografiska uppgifter
Huvudupphovsmän: Liu, Ruijie, Ramani, Biswarathan, Soto, Dagoberto, De Arcangelis, Vania, Xiang, Yang
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2009
Ämnen:
Mechanisms of Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781641/
https://ncbi.nlm.nih.gov/pubmed/19706594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.021428
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