Equilibrium between Adenylyl Cyclase and Phosphodiesterase Patterns Adrenergic Agonist Dose-Dependent Spatiotemporal cAMP/Protein Kinase A Activities in Cardiomyocytes

β-Adrenergic receptor induces cAMP/Protein kinase A (PKA) activation to regulate cardiac contraction. Using real-time fluorescence resonance energy transfer imaging for highly sensitive detection of cAMP and PKA activities, we show two distinct phases in isoproterenol dose-dependent responses in car...

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Главные авторы: De Arcangelis, Vania, Liu, Shubai, Zhang, Dawen, Soto, Dagoberto, Xiang, Yang K.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939479/
https://ncbi.nlm.nih.gov/pubmed/20530128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.064444
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