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Phosphodiesterase 4 and Phosphatase 2A Differentially Regulate cAMP/Protein Kinase A Signaling for Cardiac Myocyte Contraction under Stimulation of β(1) Adrenergic Receptor
Activation of the β adrenergic receptor (βAR) induces a tightly controlled cAMP/protein kinase A (PKA) activity to ensure an agonist dose-dependent and saturable contraction response in animal heart. We have found that stimulation of β(1)AR by isoproterenol induces maximal contraction responses at t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2654611/ https://ncbi.nlm.nih.gov/pubmed/18703669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.049718 |
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