Dynamic PKA activities induced by β adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction

cAMP/PKA activation represents a key signaling mechanism for neurohormonal stimulation of diversified physiological processes. Using real-time, FRET-based imaging of PKA activity in neonatal cardiac myocytes, we report that sustained activation of PKA induced by β adrenoceptor (βAR) dictates signali...

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Hlavní autoři: Soto, Dagoberto, De Arcangelis, Vania, Zhang, Jin, Xiang, Yang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075876/
https://ncbi.nlm.nih.gov/pubmed/19213958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.187880
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