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Dynamic PKA activities induced by β adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction
cAMP/PKA activation represents a key signaling mechanism for neurohormonal stimulation of diversified physiological processes. Using real-time, FRET-based imaging of PKA activity in neonatal cardiac myocytes, we report that sustained activation of PKA induced by β adrenoceptor (βAR) dictates signali...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3075876/ https://ncbi.nlm.nih.gov/pubmed/19213958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.187880 |
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