Binding of amyloid β peptide to β(2) adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity

Progressive decrease in neuronal function is an established feature of Alzheimer’s disease (AD). Previous studies have shown that amyloid β (Aβ) peptide induces acute increase in spontaneous synaptic activity accompanied by neurotoxicity, and Aβ induces excitotoxic neuronal death by increasing calci...

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Bibliografiske detaljer
Main Authors: Wang, Dayong, Govindaiah, G., Liu, Ruijie, De Arcangelis, Vania, Cox, Charles L., Xiang, Yang K.
Format: Artigo
Sprog:Inglês
Udgivet: The Federation of American Societies for Experimental Biology 2010
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923357/
https://ncbi.nlm.nih.gov/pubmed/20395454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-156661
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