A Long Lasting β(1) Adrenergic Receptor Stimulation of cAMP/Protein Kinase A (PKA) Signal in Cardiac Myocytes

Small-molecule, ligand-activated G protein-coupled receptors are generally thought to be rapidly desensitized within a period of minutes through receptor phosphorylation and internalization after repeated or prolonged stimulation. This transient G protein-coupled receptor activation remains at odds...

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Hlavní autoři: Fu, Qin, Kim, Sungjin, Soto, Dagoberto, De Arcangelis, Vania, DiPilato, Lisa, Liu, Shubai, Xu, Bing, Shi, Qian, Zhang, Jin, Xiang, Yang K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031532/
https://ncbi.nlm.nih.gov/pubmed/24713698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.542589
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