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Stereochemistry of an Agonist Determines Coupling Preference of β(2)-Adrenoceptor to Different G Proteins in Cardiomyocytes
A fundamental question regarding receptor-G protein interaction is whether different agonists can lead a receptor to different intracellular signaling pathways. Our previous studies have demonstrated that although most β(2)-adrenoceptor agonists activate both G(s) and G(i) proteins, fenoterol, a ful...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Pharmacology and Experimental Therapeutics
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2654765/ https://ncbi.nlm.nih.gov/pubmed/18838481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.051078 |
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