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The effect of stereochemistry on the thermodynamic characteristics of the binding of fenoterol stereoisomers to the β2-adrenoceptor

The binding thermodynamics of the stereoisomers of fenoterol, (R,R')-, (S,S')- , (R,S')-, and (S,R')-fenoterol, to the β(2)-adrenergic receptor (β(2)-AR) have been determined. The experiments utilized membranes obtained from HEK cells stably transfected with cDNA encoding human β...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jozwiak, Krzysztof, Toll, Lawrence, Jimenez, Lucita, Woo, Anthony Yiu-Ho, Xiao, Rui-Ping, Wainer, Irving W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850566/
https://ncbi.nlm.nih.gov/pubmed/20144591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.01.035
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