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Comparative Molecular Field Analysis of Fenoterol Derivatives: A Platform Towards Highly Selective and Effective β(2) Adrenergic Receptor Agonists

PURPOSE: to use a previously developed CoMFA model to design a series of new structures of high selectivity and efficacy towards the β(2) adrenergic receptor. RESULTS: Out of 21 computationally designed structures 6 compounds were synthesized and characterized for β(2)-AR binding affinities, subtype...

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Bibliografski detalji
Glavni autori: Jozwiak, Krzysztof, Yiu-Ho Woo, Anthony, Tanga, Mary J., Toll, Lawrence, Jimenez, Lucita, Kozocas, Joseph A., Plazinska, Anita, Xiao, Rui-Ping, Wainer, Irving W.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832585/
https://ncbi.nlm.nih.gov/pubmed/20036561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.11.062
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