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Comparative Molecular Field Analysis of Fenoterol Derivatives: A Platform Towards Highly Selective and Effective β(2) Adrenergic Receptor Agonists
PURPOSE: to use a previously developed CoMFA model to design a series of new structures of high selectivity and efficacy towards the β(2) adrenergic receptor. RESULTS: Out of 21 computationally designed structures 6 compounds were synthesized and characterized for β(2)-AR binding affinities, subtype...
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| Asıl Yazarlar: | , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2832585/ https://ncbi.nlm.nih.gov/pubmed/20036561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.11.062 |
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