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Stereochemistry of an Agonist Determines Coupling Preference of β(2)-Adrenoceptor to Different G Proteins in Cardiomyocytes

A fundamental question regarding receptor-G protein interaction is whether different agonists can lead a receptor to different intracellular signaling pathways. Our previous studies have demonstrated that although most β(2)-adrenoceptor agonists activate both G(s) and G(i) proteins, fenoterol, a ful...

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Bibliografski detalji
Glavni autori: Woo, Anthony Yiu-Ho, Wang, Tian-Bing, Zeng, Xiaokun, Zhu, Weizhong, Abernethy, Darrell R., Wainer, Irving W., Xiao, Rui-Ping
Format: Artigo
Jezik:Inglês
Izdano: American Society for Pharmacology and Experimental Therapeutics 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654765/
https://ncbi.nlm.nih.gov/pubmed/18838481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.051078
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