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Selective Small Molecule Targeting β-Catenin Function Discovered by In Vivo Chemical Genetic Screen
Canonical Wnt signaling pathway, mediated by the transcription factor β-catenin, plays critical roles in embryonic development, and represents an important therapeutic target. In a zebrafish-based in vivo screen for small molecules that specifically perturb embryonic dorsoventral patterning, we disc...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3923627/ https://ncbi.nlm.nih.gov/pubmed/24012757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.07.047 |
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